Wayne A. Hendrickson (born April 25, 1941, New York City) is an American biophysicist and university professor at Columbia University. Dr. Hendrickson is a university professor at Columbia University in the department of biochemistry and molecular biophysics[1]. He is also Chief Life Scientist in the Photon Sciences Directorate at Brookhaven National Laboratory and scientific director of the New York Structural Biology Center[1].

Early life and education

Hendrickson grew up on a farm in Spring Valley, Wisconsin, the son of Norwegian immigrants.[2] He obtained a B.A. in biophysics from University of Wisconsin-River Falls[2][3]. He later received his Ph.D. in biophysics from Johns Hopkins University with Warner Love[2], and postdoctoral research experience with Jerome Karle at the Naval Research Laboratory (NRL).

Scientific contributions

Hendrickson is best known for innovating the use of multi-wavelength anomalous dispersion as an analytical tool for protein crystallography[4][5].

Hendrickson and his colleagues use biochemistry and x-ray crystallography to study molecular properties in atomic detail with current emphasis on membrane receptors and cellular signaling[6][7][8], on viral proteins and HIV infection[9][10], on molecular chaperones and protein folding[11][12][13], and on structural genomics of membrane proteins[14][15][16][17][18].

Recognition

Hendrickson's honors include the Aminoff Prize of the Royal Swedish Academy of Sciences[19], Christian B. Anfinsen Award[20] the Gairdner Foundation International Award[21], the Harvey Prize[22], and the thirteenth IUCr Ewald Prize in 2023.[23] He is a fellow of the American Academy of Arts and Sciences[24][25] and a member of the National Academy of Sciences[26]. On June 2, 1995 he received an honorary doctorate from the Faculty of Science and Technology at Uppsala University, Sweden[27]

References

  1. 1 2 "HENDRICKSON, WAYNE A., Ph.D." Department of Physiology and Cellular Biophysics. Columbia University Medical Center. Retrieved 19 May 2026.
  2. 1 2 3 Zierler, David (13 April 2020). "Biography - Wayne Hendrickson". ACA History. American Crystallographic Association. Retrieved 19 May 2026.
  3. ↑ "Distinguished Alumni Recipients". University of Wisconsin River Falls. Retrieved 19 May 2026.
  4. ↑ Hendrickson W, Ogata C (1997). "Phase determination from multiwavelength anomalous diffraction measurements". Macromolecular Crystallography Part A. Methods in Enzymology. Vol. 276. pp. 494–523. doi:10.1016/S0076-6879(97)76074-9. ISBN 978-0-12-182177-7. PMID 27799111.
  5. ↑ Hendrickson WA (1985). "Analysis of Protein Structure from Diffraction Measurement at Multiple Wavelengths". Transactions of the ACA. 21.
  6. ↑ Leahy, Daniel J.; Axel, Richard; Hendrickson, Wayne A. (March 1992). "Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution". Cell. 68 (6): 1145–1162. doi:10.1016/0092-8674(92)90085-Q.
  7. ↑ Ryu, Seong-Eon; Kwong, Peter D.; Truneh, Alemseged; Porter, Terence G.; Arthos, James; Rosenberg, Martin; Dai, Xiaoping; Xuong, Nguyen-huu; Axel, Richard; Sweet, Raymond W.; Hendrickson, Wayne A. (November 1990). "Crystal structure of an HIV-binding recombinant fragment of human CD4". Nature. 348 (6300): 419–426. doi:10.1038/348419a0.
  8. ↑ Wu, Hao; Kwong, Peter D.; Hendrickson, Wayne A. (May 1997). "Dimeric association and segmental variability in the structure of human CD4". Nature. 387 (6632): 527–530. doi:10.1038/387527a0.
  9. ↑ Wyatt, Richard; Kwong, Peter D.; Desjardins, Elizabeth; Sweet, Raymond W.; Robinson, James; Hendrickson, Wayne A.; Sodroski, Joseph G. (June 1998). "The antigenic structure of the HIV gp120 envelope glycoprotein". Nature. 393 (6686): 705–711. doi:10.1038/31514.
  10. ↑ Kwong, Peter D.; Wyatt, Richard; Robinson, James; Sweet, Raymond W.; Sodroski, Joseph; Hendrickson, Wayne A. (June 1998). "Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody". Nature. 393 (6686): 648–659. doi:10.1038/31405.
  11. ↑ Qi, Ruifeng; Sarbeng, Evans Boateng; Liu, Qun; Le, Katherine Quynh; Xu, Xinping; Xu, Hongya; Yang, Jiao; Wong, Jennifer Li; Vorvis, Christina; Hendrickson, Wayne A; Zhou, Lei; Liu, Qinglian (July 2013). "Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP". Nature Structural & Molecular Biology. 20 (7): 900–907. doi:10.1038/nsmb.2583.
  12. ↑ Liu, Qinglian; Hendrickson, Wayne A. (October 2007). "Insights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1". Cell. 131 (1): 106–120. doi:10.1016/j.cell.2007.08.039.
  13. ↑ Wang, Wei; Liu, Qinglian; Liu, Qun; Hendrickson, Wayne A. (October 2021). "Conformational equilibria in allosteric control of Hsp70 chaperones". Molecular Cell. 81 (19): 3919–3933.e7.
  14. ↑ Chang, Yanqi; Bruni, Renato; Kloss, Brian; Assur, Zahra; Kloppmann, Edda; Rost, Burkhard; Hendrickson, Wayne A.; Liu, Qun (6 June 2014). "Structural basis for a pH-sensitive calcium leak across membranes". Science. 344 (6188): 1131–1135. doi:10.1126/science.1252043.
  15. ↑ Yang, Tingting; Liu, Qun; Kloss, Brian; Bruni, Renato; Kalathur, Ravi C.; Guo, Youzhong; Kloppmann, Edda; Rost, Burkhard; Colecraft, Henry M.; Hendrickson, Wayne A. (17 October 2014). "Structure and selectivity in bestrophin ion channels". Science. 346 (6207): 355–359. doi:10.1126/science.1259723.
  16. ↑ Hendrickson, Wayne A (June 2016). "Atomic-level analysis of membrane-protein structure". Nature Structural & Molecular Biology. 23 (6): 464–467. doi:10.1038/nsmb.3215.
  17. ↑ Love, James; Mancia, Filippo; Shapiro, Lawrence; Punta, Marco; Rost, Burkhard; Girvin, Mark; Wang, Da-Neng; Zhou, Ming; Hunt, John F.; Szyperski, Thomas; Gouaux, Eric; MacKinnon, Roderick; McDermott, Ann; Honig, Barry; Inouye, Masayori; Montelione, Gaetano; Hendrickson, Wayne A. (September 2010). "The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins". Journal of Structural and Functional Genomics. 11 (3): 191–199. doi:10.1007/s10969-010-9094-7.
  18. ↑ Qiu, Weihua; Fu, Ziao; Xu, Guoyan G.; Grassucci, Robert A.; Zhang, Yan; Frank, Joachim; Hendrickson, Wayne A.; Guo, Youzhong (18 December 2018). "Structure and activity of lipid bilayer within a membrane-protein transporter". Proceedings of the National Academy of Sciences. 115 (51): 12985–12990. doi:10.1073/pnas.1812526115.
  19. ↑ Olovsson, Ivar (5 February 2019). "The Gregori Aminoff prize". IUCr Newsletter. 5 (2). Retrieved 19 May 2026.
  20. ↑ "Recent honours". IUCr Newsletter. 5 (1). 2 November 2018. Retrieved 19 May 2026.
  21. ↑ "Canada Gairdner International Award". Gairdner. Retrieved 19 May 2026.
  22. ↑ "Prize Winners". Harvey Prize. Retrieved 19 May 2026.
  23. ↑ "Thirteenth Ewald Prize"
  24. ↑ "Wayne A. Hendrickson". American Academy of Arts & Sciences. Retrieved 19 May 2026.
  25. ↑ "Book of Members, 1780–2010: Chapter h" (PDF). American Academy of Arts and Sciences. Retrieved June 19, 2011.
  26. ↑ "Wayne A. Hendrickson". National Academy of Sciences. Retrieved 19 May 2026.
  27. ↑ "Honorary doctorates - Uppsala University, Sweden".
source: https://en.wikipedia.org/wiki/Wayne_Hendrickson