Tegileridine, sold under the brand name Aisute, is a drug which acts as a μ-opioid receptor agonist. It is closely related to compounds such as oliceridine, TRV734, and SHR9352, and shares a similar profile as a biased agonist selective for activation of the G protein signalling pathway over β-arrestin2 recruitment.[1]

In January 2024, tegileridine was approved in China under the brand name Aisute for the treatment of moderate to severe pain after abdominal surgery.[2]

See also

References

  1. ^ WO 2017/063509, "Oxa spiro derivative, preparation method therefor, and applications thereof in medicines", published 10 April 2018, assigned to Jiangsu Hengrui Medicine Company and Shanghai Hengrui Pharmaceutical Company Ltd . 
  2. ^ Dhillon S (June 2024). "Tegileridine: First Approval". Drugs. 84 (6): 717–720. doi:10.1007/s40265-024-02033-4. PMID 38771484.
source: https://en.wikipedia.org/wiki/Tegileridine