Sodium butyrate is a compound with formula CH3CH2CH2COO−Na+.[1] It is the sodium salt of butyric acid. It is a white, water-soluble, crystalline solid having the odor of butyric acid.[1]

Occurrence

Sodium butyrate is a common source of butyrate which forms when butyric acid is dissolved near neutral pH.[1] Butyrate is a common metabolite that is produced by hydrolysis of butyryl-CoA.[2]

Medical research

Butyrate affects histone deacetylase, which is tied to DNA processing.[3] Sodium butyrate is under preliminary research for its potential to mitigate traveler's diarrhea.[4]

References

  1. 1 2 3 "Sodium butyrate". PubChem, US National Library of Medicine. 11 July 2026. Retrieved 13 July 2026.
  2. ↑ Nelson, David L.; Cox, Michael M. (2005). Principles of Biochemistry (4th ed.). New York: W. H. Freeman. ISBN 0-7167-4339-6.
  3. ↑ Davie, James R. (2003). "Inhibition of Histone Deacetylase Activity by Butyrate". The Journal of Nutrition. 133 (7): 2485S–2493S. doi:10.1093/jn/133.7.2485s. PMID 12840228.
  4. ↑ Fan H, Gao L, Yin Z, Ye S, Zhao H, Peng Q (October 2022). "Probiotics and rifaximin for the prevention of travelers' diarrhea: A systematic review and network meta-analysis". Medicine (Baltimore). 101 (40) e30921. doi:10.1097/MD.0000000000030921. PMC 9542755. PMID 36221413.
source: https://en.wikipedia.org/wiki/Sodium_butyrate