Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.[5][6]

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.[6]

Ligands

Privosegtor, an activator of the SGK2 enzyme, is being developed for the treatment of optic neuritis.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101049 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017868 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". The Biochemical Journal. 344 (1): 189–197. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
  6. 1 2 "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".
  7. ↑ "Privosegtor - Oculis Pharma". AdisInsight. Springer Nature Switzerland AG.

Further reading

  • Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Science's STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. S2CID 25927734.
  • Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, et al. (October 2002). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflugers Archiv. 445 (1): 60–66. doi:10.1007/s00424-002-0873-2. PMID 12397388. S2CID 21073737.
  • Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, et al. (March 2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflugers Archiv. 445 (6): 693–696. doi:10.1007/s00424-002-0993-8. PMID 12632189. S2CID 32511608.
  • Embark HM, Böhmer C, Vallon V, Luft F, Lang F (February 2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflugers Archiv. 445 (5): 601–606. doi:10.1007/s00424-002-0982-y. PMID 12634932. S2CID 22981271.
  • Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G (April 2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflugers Archiv. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212. S2CID 190895.
  • Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, et al. (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725). New York, N.Y.: 1149–1154. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
source: https://en.wikipedia.org/wiki/SGK2