Flopropione (Compacsul, Cospanon, Ecapron, Pellegal, Argobyl, Floveton, Saritron, Spamorin, Labrodax, Tryalon, Mirulevatin, Padeskin, Profenon) is a spasmolytic or antispasmodic agent.[1] It acts as a COMT inhibitor.[2] The drug has also been said to be a serotonin 5-HT1A receptor antagonist.[1][3] It is synthesized from phloroglucinol in a Hoesch reaction.[citation needed]

See also

References

  1. 1 2 Buckingham J, MacDonald F (26 September 1996). Dictionary of Organic Compounds ... - Google Books. CRC Press. ISBN 978-0-412-54110-0. 1-(2,4,6-Trihydroxyphenyl)-1-propanone, 9CI. T-1-00232. 2',4',6'-Trihydroxypropiophenone. Flopropione, INN. Phloropropiophenone. Fluropropiophenone. Compacsul. Cospanon. Mirulevatin. Padeskin. Profenont Ecapron. Pellegal. Argobyl. Floveton. Saritron. Spamorin. Labrodax. Tryalon. [2295-58-1] C9H1004 M 182.1 Constit. of Inula viscosa. 5-HTA receptor antagonist, spasmolytic agent. Needles + 1H2O (H₂O). Sl. sol. H₂O. Mp 175-176°.
  2. ↑ "Cospanon label" (PDF). Archived from the original (PDF) on 2016-10-07. Retrieved 2016-03-14.
  3. ↑ Pal Singh I, Bharate SB (August 2006). "Phloroglucinol compounds of natural origin". Nat Prod Rep. 23 (4): 558–591. doi:10.1039/b600518g. PMID 16874390. Several simple acyl phloroglucinols, such as phloroisovalerophenone (4) and its propyl analogue, flopropione (5), also occur in nature and have been isolated from hops Humulus lupulus33 and Inula viscosa34 respectively. Flopropione (5) showed 5-HT1A receptor antagonistic activity, as well as spasmolytic activity.35
source: https://en.wikipedia.org/wiki/Flopropione