CTW0415 is an experimental drug from the piperidine family, which acts as a selective positive allosteric modulator of the 5-HT2C receptor, with higher potency than older drugs such as VA012. Structure-activity relationship studies showed that small variations to chain length and side chain substitution could lead to preferential binding for either 5-HT2C or the related 5-HT2A receptor, which subsequently led to the discovery of the related 5-HT2A selective positive allosteric modulator CTW0404.[1][2][3]

References

  1. ↑
  2. ↑ WO 2023/023287, Zhou J, Cunningham KA, Bolinger AA, Anastasio NC, "Novel heterocyclic compounds as serotonin (5-ht) 5-ht2a and 5-ht2c receptor positive allosteric modulators.", published 22 February 2024, assigned to The Board of Regents of the University of Texas System



source: https://en.wikipedia.org/wiki/CTW0415