5-HO-DiPT, also known as 5-hydroxy-N,N-di-iso-propyltryptamine, is a tryptamine derivative which acts as a serotonin receptor agonist. It is primarily known as a metabolite of the better known psychoactive drug 5-MeO-DiPT,[1] but 5-HO-DiPT has also rarely been encountered as a designer drug in its own right.[2] Tests in vitro show 5-HO-DiPT to have high serotonin 5-HT2A receptor affinity and good selectivity over the serotonin 5-HT1A receptor,[3] while being more lipophilic than the related drug bufotenine (5-HO-DMT), which produces primarily peripheral effects.

Interactions

Chemistry

Analogues

Analogues of 5-HO-DiPT include diisopropyltryptamine (DiPT), 4-HO-DiPT (iprocin), 4-AcO-DiPT (ipracetin), 5-MeO-DiPT, bufotenin (5-HO-DMT), 5-AcO-DMT, 5-HO-MET, 5-HO-DET, 5-HO-DPT, and α-methylserotonin (5-HO-AMT), among others.

See also

References

  1. ↑ Yu AM (June 2008). "Indolealkylamines: biotransformations and potential drug-drug interactions". The AAPS Journal. 10 (2): 242–53. doi:10.1208/s12248-008-9028-5. PMC 2751378. PMID 18454322.
  2. ↑ Brandt SD, Martins CU (2010). "Analytical methods for psychoactive N,N-dialkylated tryptamines". TrAC Trends in Analytical Chemistry. 29 (8): 858–869. doi:10.1016/j.trac.2010.04.008.
  3. ↑ McKenna DJ, Repke DB, Lo L, Peroutka SJ (March 1990). "Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes". Neuropharmacology. 29 (3): 193–8. doi:10.1016/0028-3908(90)90001-8. PMID 2139186. S2CID 24188017.
source: https://en.wikipedia.org/wiki/5-HO-DiPT