4-HO-McPT, also known as 4-hydroxy-N-methyl-N-cyclopropyltryptamine, is a psychedelic tryptamine derivative. It has serotonergic effects,[1] and has reportedly been sold as a designer drug since around 2016, but was not definitively identified by forensic laboratories until 2018.[2][3]

Interactions

Pharmacology

4-HO-McPT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[4] It has been found to act as a serotonin reuptake inhibitor.[4]

Chemistry

Analogues

Analogues of 4-HO-McPT include methylcyclopropyltryptamine (McPT), N-cyclopropyltryptamine (NcPT), 4-AcO-McPT, 5-MeO-McPT, 4-HO-McPeT, 4-HO-MiPT, 4-HO-MALT, 4-HO-MiPT, 4-HO-MPT, and 4-HO-EPT, among others.

Society and culture

Finland

4-HO-McPT is illegal in Finland.[5]

See also

References

  1. ↑ US application 2019142851, Chadeayne, Andrew R, "Compositions comprising a psilocybin derivative and a cannabinoid", published 2019-05-16, assigned to CaaMTech LLC, now abandoned.
  2. ↑ Chapman SJ (March 2018). "PeakAL: Protons I Have Known and Loved, Too — Another Fifty Shades of Grey-Market Spectra". Blotter. 3 (1). doi:10.16889/isomerdesign-5.
  3. ↑ "Analytical Report: 4-HO-McPT" (PDF). Nacionalni Forenzični Laboratorij. Slovenia. September 2018.
  4. 1 2 Glatfelter GC, Schalk SS, Walther D, Maitland AD, Gonzalez NR, Partilla JS, Anas NA, Chadeayne AR, Naeem M, Manke DR, McCorvy JD, Baumann MH (May 2026). "Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs". ACS Chem Neurosci. doi:10.1021/acschemneuro.6c00083. PMID 42200433.
  5. ↑ Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista
source: https://en.wikipedia.org/wiki/4-HO-McPT