2-Furylethylamine (2-FEA or FEA) is a drug of the arylalkylamine family related to the substituted phenethylamines such as β-phenethylamine (PEA) and amphetamine.[1] It is known to have similar pressor effects as amphetamine and strong constricting effects on the uterus in animals.[1][2][3] The psychoactive effects of FEA in humans are unknown.[1]

Derivatives of FEA include α-Me-FEA (furylisopropylamine) and α,N-Me-FEA, among others.[1][2] α-Me-FEA was less several-fold potent than amphetamine in animals and showed limited effects in humans.[2] Analogues of FEA, besides β-phenethylamine (PEA) and amphetamine (α-Me-PEA), include TH-FEA, α-Me-TH-FEA, ThEA, thiopropamine (α-Me-ThEA), 3-ThEA, 2-(2-pyrrolyl)ethylamine (NEA), and α-Me-NEA, among others.[1][2] Some of them are known to be active.[1][2]

FEA was first synthesized by 1920.[1][3] FEA and analogues were studied by Gordon Alles and colleagues, who discovered its pressor effects.[1][2] FEA is not a controlled substance in the United States as of 2011.[1]

References

  1. 1 2 3 4 5 6 7 8 9 Shulgin A, Manning T, Daley PF (2011). "#67. FEA". The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley, CA: Transform Press. pp. 138–141. ISBN 978-0-9630096-3-0. OCLC 709667010.
  2. 1 2 3 4 5 6 Alles GA, Feigen GA (1941). "Comparative physiological actions of phenyl-, thienyl-, and furylisopropylamines". Journal of Pharmacology and Experimental Therapeutics. 72 (3): 265–275. doi:10.1016/S0022-3565(25)03876-5.
  3. 1 2 Windaus A, Dalmer O (1920). "Furethylamine and tetrahydrofurethylamine". Berichte Deutsch. Chem. Ges. 53B: 2304–2308. doi:10.1002/cber.19200531118.


source: https://en.wikipedia.org/wiki/2-Furylethylamine